AA Pharma Imipramine Adverse Reactions

Although the listing which follows includes a few adverse reactions which have not been reported with this specific drug, the pharmacological similarities among the tricyclic antidepressant drugs require that each of the reactions be considered when imipramine is administered.
Cardiovascular: Hypotension, hypertension, tachycardia, palpitation, myocardial infarction, arrhythmias, heart block, stroke, falls. A few instances of unexpected death have occurred in patients with cardiovascular disorders.
Psychiatric: Confusional states (especially in the elderly) with hallucinations, disorientation, delusions, anxiety, restlessness, agitation; insomnia and nightmares; hypomania; exacerbation of psychosis.
Neurological: Numbness, tingling, paresthesias of extremities, incoordination, ataxia, tremors; peripheral neuropathy; extrapyramidal symptoms, seizures, alterations in EEG patterns; tinnitus.
Anticholinergic: Dry mouth, and rarely, associated sublingual adenitis, blurred vision, disturbances of accommodation, mydriasis; constipation, paralytic ileus; urinary retention, delayed micturition, dilation of the urinary tract.
Allergic: skin rash, petechiae, urticaria, itching, photosensitization (avoid excessive exposure to sunlight); edema (general or of face and tongue), drug fever, cross-sensitivity with desipramine.
Hematologic: Bone marrow depression including agranulocytosis; eosinophilia, purpura, thrombocytopenia. Leukocyte and differential counts should be performed in any patient who develops fever and sore throat during therapy; the drug should be discontinued if there is evidence of pathological neutrophil depression.
Gastrointestinal: Nausea and vomiting, anorexia, epigastric distress, diarrhoea; peculiar taste, stomatitis, abdominal cramps, black tongue.
Endocrine: Gynecomastia in the male, breast enlargement and galactorrhea in the female, increased or decreased libido, impotence; testicular swelling; elevation or depression of blood sugar levels.
Other: Jaundice (simulating obstructive); urinary frequency, drowsiness, dizziness, weakness and fatigue, headache; parotid swelling, alopecia.
Withdrawal symptoms: Though not indicative of addiction, abrupt cessation of treatment after prolonged therapy may produce nausea, headache and malaise.